Correction: Dynamics of Sun5 Localization during Spermatogenesis in Wild Type and Dpy19l2 Knock-Out Mice Indicates That Sun5 Is Not Involved in Acrosome Attachment to the Nuclear Envelope
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There is an error in the third author’s name. The correct surname for the third author is: Abi Nahed. The correct given name is: Roland. The correct citation is: Yassine S, Escoffier J, Abi Nahed R, Pierre V, Karaouzene T, Ray PF, et al. (2015) Dynamics of Sun5 Localization during Spermatogenesis in Wild Type and Dpy19l2 Knock-Out Mice Indicates That Sun5 Is Not Involved in Acrosome Attachment to the Nuclear Envelope. PLoS ONE 10(3): e0118698. doi:10. 1371/journal.pone.0118698 The publisher apologizes for the error.
منابع مشابه
Dynamics of Sun5 Localization during Spermatogenesis in Wild Type and Dpy19l2 Knock-Out Mice Indicates That Sun5 Is Not Involved in Acrosome Attachment to the Nuclear Envelope
The acrosome is an organelle that is central to sperm physiology and a defective acrosome biogenesis leads to globozoospermia, a severe male infertility. The identification of the actors involved in acrosome biogenesis is therefore particularly important to decipher the molecular pathogeny of globozoospermia. We recently showed that a defect in the DPY19L2 gene is present in more than 70% of gl...
متن کاملComparative testicular transcriptome of wild type and globozoospermic Dpy19l2 knock out mice
BACKGROUND Globozoospermia is a male infertility phenotype characterized by the presence in the ejaculate of near 100% acrosomeless round-headed spermatozoa with normal chromosomal content. Following intracytoplasmic sperm injection (ICSI) these spermatozoa give a poor fertilization rate and embryonic development. We showed previously that most patients have a 200 kb homozygous deletion, which ...
متن کاملSun proteins and Dpy19l2 forming LINC-like links are critical for spermiogenesis
We have read with a great interest the excellent article by Pasch et al. (2015) which describes the role of Sun4 in sperm head formation and fertility. The authors have used a Sun4 knockout (Sun4) mouse model to study the function of Sun4 in spermatogenesis. They observed that homozygous Sun4 males are infertile and present a globozoospermia-like phenotype. Further, they demonstrate that Sun4 i...
متن کاملAbsence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.
Sperm-head elongation and acrosome formation, which take place during the last stages of spermatogenesis, are essential to produce competent spermatozoa that are able to cross the oocyte zona pellucida and to achieve fertilization. During acrosome biogenesis, acrosome attachment and spreading over the nucleus are still poorly understood and to date no proteins have been described to link the ac...
متن کاملEssential role for SUN5 in anchoring sperm head to the tail
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function. Here, we generated Sun5-/- mice and found that male mice were infertile. Most Sun5-null spermatozoa displayed a globozoospermia-like phenotype but they were actually...
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